Sino-Nasal Outcome Test — SNOT  Author: Jay Piccirillo, MD Chronic rhinosinusitis (CRS) is the second most frequent reported chronic health condition (after arthritis), affects up to 14% of the US population, and results in significant disease burden in patients (Adams, Hendershot, and Marano 1996). The best approximation of CRS disease burden, defined as its impact on patient’s functional status and disease-related quality of life, is to use patient-reported outcome measures (PROM) (Benninger et al. 2003; Morley and Sharp 2006). The most widely used PROM for CRS patients is the Sino-Nasal Outcome Test (SNOT) instrument. The SNOT instrument is a collection of several validated instruments (SNOT-16, SNOT-20, SNOT-22) defined by the number of included items. All of the SNOT instruments are derived from the Rhino-Sinusitis Outcome Measure (RSOM-31) (Piccirillo et al. 1995). The scores of each question range from 0 to 5, according to the severity of the symptom, with 5 being the worst. The score of the test is the sum of the question scores. Higher scores represent a lower health related-quality of life. In addition, patients identify the five items that affect them the most. Typically, the impact of treatment is assessed with the SNOT Absolute Change Score. The SNOT-16, SNOT-20, and SNOT-22 are copyright protected by Washington University in St. Louis.

SNOT Instrument Standard License Terms

Non-Profit, Academic Use

  • Licensee Fee
    • $500/yr for unlimited use
  • Term
    • Limited to up to 3 years

Clinical Trial Use*

  • Licensee Fee
    • Large entity $35/use
    • Small entity** $20/use
  • Minimum Licensee Fee $10,000
  • Term
    • Limited to up to 3 years
  • Languages
    • All available languages included

Clinical Use

  • Licensee Fee
    • $500/year per Clinical Group, defined as a medical office with up to 20 Healthcare Providers

Washington University in St. Louis has the right to make the final determination if the Licensee’s use case fits our Standard License Terms.

*For Phase I Trials. Please contact us for pricing for other Trial Stages:

**Entity that does not, together with all affiliates, have 500 or more employees

To license SNOT, please fill out the form below and a WashU licensing manager will send you the appropriate license agreement.

SNOT New Form
Licensee Address
If a translation is not listed, then please inquire as new translations are in progress.

This form is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Additional Information can be provided about the study and additional information may be requested by Washington University in St. Louis Office of Technology Management.


Craig Weilbaecher, PhD

Business Development Associate

Print Friendly, PDF & Email