Source: JCI Insight – December 7, 2017
Thanks to a new study headed by Ying Maggie Chen, MD, PhD, it may soon be possible to diagnose certain human kidney diseases in their earliest stages of development using a noninvasive biomarker of endoplasmic reticulum (ER) stress. The study, Elevated Urinary CRELD2 is Associated with Endoplasmic Reticulum Stress-mediated Kidney Disease, was published online in the journal JCI Insight, December 7, 2017.
The ER is the central site for folding, post-translational modifications and transport of secretory and membrane proteins. When there is a mismatch between the load of unfolded/misfolded proteins and the folding capacity, “ER stress” occurs. If ER stress is prolonged or is too severe, cell suicide can be triggered, usually in the form of apoptosis.Read Full Article