Broad Clinical Applications for CRELD2 as an ER Stress Biomarker

Source: JCI Insight – December 7, 2017

Thanks to a new study headed by Ying Maggie Chen, MD, PhD, it may soon be possible to diagnose certain human kidney diseases in their earliest stages of development using a noninvasive biomarker of endoplasmic reticulum (ER) stress. The study, Elevated Urinary CRELD2 is Associated with Endoplasmic Reticulum Stress-mediated Kidney Disease, was published online in the journal JCI Insight, December 7, 2017.

The ER is the central site for folding, post-translational modifications and transport of secretory and membrane proteins. When there is a mismatch between the load of unfolded/misfolded proteins and the folding capacity, “ER stress” occurs. If ER stress is prolonged or is too severe, cell suicide can be triggered, usually in the form of apoptosis.

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